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Description
After three months of intragastric Dihexa administration (1.44 or 2.88 mg/kg), the APP/PS1 mice showed restored Morris water maze performance, increased neuronal cell counts and synaptophysin expression on Nissl staining, reduced microglial and astrocyte activation, decreased pro-inflammatory cytokines (IL-1, TNF-) and increased anti-inflammatory IL-10
Possible side effects may include: Pain, redness, or swelling at the injection site Mild nausea or stomach upset Headache or dizziness in some individuals Allergic reaction (rare)
In addition, the multifunctional FN III9-10/12-14 greatly enhanced the regenerative effects of BMP-2 and PDGF-BB in a rat critical-size bone defect model [186]
[Google Scholar] 35.Okesola BO, Ni S, Derkus B, Galeano CC, Hasan A, Wu Y, Ramis J, Buttery L, Dawson JI, DEste M, et al
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