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Furthermore, by reducing CCO activity and compromising oxidative phosphorylation, copper deficiency compels cardiomyocytes to rely more heavily on anaerobic glycolysis, thereby reinforcing the metabolic shift that underpins pathological reprogramming [104]

[DOI] [PubMed] [Google Scholar] Teshima H., Kato M., Tatsukawa H., Hitomi K

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This results in a therapeutically motivated training set that targets the models most severe areas of uncertainty