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Mechanism of Action Figure 1 shows a schematic of the general mechanism of action of SUs

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These processes occur when there is an imbalance between lipid oxidation and the antioxidant system, leading to cell rupture and death and eventually ferroptosis ( Enzymatic Lipid Peroxidation Enzymatic lipid peroxidation is mainly mediated by the lipoxygenase (LOX) family, which is a group of haeme-type iron-containing enzymes that catalyse PUFAs, primarily adrenergic acid (Ada) and arachidonic acid (AA)

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Kim, M., Fevre, C., Lavina, M., Disson, O