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Other systemic protein misfolding disorders, such as transthyretin (TTR) amyloidosis, further demonstrate how destabilization of otherwise soluble proteins can lead to pathogenic aggregation

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Glutathione synthesis can be impaired by cysteine depletion, protein-energy malnutrition, hyperglycemia, glucocorticoid at pharmacologic doses, and decreased secretion of anterior pituitary hormones (growth hormones, thyrotropin, gonadotropins), as often observed in prolonged critical illness

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