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Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone

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Moreover, given the potential links between adipose tissue metabolism and the gut microbiome, correlations between the cecal microbiome and adipose tissue metabolites were examined

If symptoms worsen or new ones appear, re-evaluate (e.g., neurological exam, additional testing)

The dose figures above are the documented per-dose amounts

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