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Bioanalysis 12 (7), 485500

S.MurthyH

Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA

This charge-switching mechanism, exemplified by PEG- b -poly(-lysine)-hydrazone- doxorubicin micelles from the cited study, enables targeted drug delivery with improved intracellular release and reduced systemic toxicity, highlighting the therapeutic advantage of pH-sensitive hydrazone bonds in nanocarrier design [46]

DOI: 10.1016/j.immuni.2020.04.023 Antibodies Reject Viral Entry by Exploiting the SARS-CoV-2 Spike Protein One of the key strengths of SARS-CoV-2 is its spike (S) protein, which enables the virus to bind tightly to its cellular receptor, ACE2

The key factor here is bioavailability
