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Interestingly, the mesenchymal shift by Day 45 suggests greater cellular complexity at later stages, potentially facilitating iHLO use in modeling liver pathologies such as fibrosis, cirrhosis, and liver remodeling, as indicated by increased expression of hepatic stellate cell markers such as DES and VIM 33,34

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Cloning and recombination of plasmids and fragments were performed using the One Step Cloning Kit provided by Vazyme (#C112, Nanjing, Jiangsu, China)

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The role of individual susceptibility should also be considered

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