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cAMP-PKA/cGMP-PKG also plays an important role in regulating Ca 2+ flux into the myocardium

In some cases, adding folate improves neurologic symptoms when B12 alone does not
In addition, underlying conditions, such as disorders affecting the kidneys, also influence the duration of the benefits of IV hydration therapy

10.1016/j.apsb.2022.01.012 Acta Pharm Sin B
2,9,10 At the start of oral vitamin B12 replacement therapy, close monthly monitoring of laboratory results and symptoms is recommended, thereafter annual monitoring should suffice

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