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[77] also proposed criteria for a cytological classification system for MCTs, dividing tumors into low- and high-grade, and concluded that the classification is useful for the initial assessment, although the reliability of cytology is considered inadequate at this point

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PIs should understand: what data goes to the DMC how frequently it is reviewed how decisions are documented and communicated how local site actions align with global oversight If your trial uses a DMC, study the structure here: DMC roles explained