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The treatment significantly improved vertebral and femoral bone tissue damage, increased bone mineral density, reduced the levels of serum TRAP-5b, PINP, IL-6, TGF- and TNF-, attenuated inflammatory responses, upregulated -catenin expression and downregulated PPAR and Axin2 expression in bone tissues, which, in turn, facilitated the activation of the Wnt/-catenin pathway

[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Fang AP, Chen PY, Wang XY, Liu ZY, Zhang DM, Luo Y, Liao GC, Long JA, Zhong RH, Zhou ZG, Xu YJ, Xu XJ, Ling WH, Chen MS, Zhang YJ, Zhu HL

5 Predictive models Predictive classification models are one of the usable outcomes of metabolomics

TGF- has been shown to downregulate activity of Glutamine Cysteine ligase, a rate-limiting step enzyme involved in the synthesis of GSH [75]

U., Lacouture, P