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Isoform a is 772 amino acids and isoform c is 738 amino acids

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It is known that, in rat and human GLCL holoenzyme, cystamine completely inactivates rat GLCL activity by interaction with a thiol group that is thought to be at or near the l-glutamate-binding site in the wild enzyme [135,136,137,138] and also in a recombinant mutant (hGLCLC-C553G) where one cysteine group far from the active site was selectively inactivated [139]

All studies found ALA to be a safe and tolerable intervention

Lumbar spine BMD Z-score at baseline was 0.72 1.14, femoral neck Z-score at baseline was 0.37 0.97 and total hip Z-score at baseline was 0.40 1.06

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