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Despite promising preclinical data, clinical trials in humans are extremely limited, and the compound remains largely experimental, with ongoing research required to fully characterize pharmacokinetics, optimal dosing, long-term safety, and potential off-target effects.

In addition, DTP cells can survive long enough during continuous drug treatment and progress to stable drug-resistant cells due to genetic evolution (Pu et al., 2023

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CD38 plays a major role in this NAD+ decline
