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163 On the other hand, COX-2 is generally synthesized in response to inflammatory stimuli in many tissues including prostate, immune cells (T-cells, B-cells, monocytes), and stomach, but is also constitutively expressed in the brain, lungs, gut, thymus, kidneys, and blood vessels

Reactivity of the human thioltransferase (glutaredoxin) C7S, C25S, C78S, C82S mutant and NMR solution structure of its glutathionyl mixed disulfide intermediate reflect catalytic specificity

Overall, similar to general autophagy, it seems that depending on the stage of tumorigenesis, mitophagy also plays a dual role in HCC development

Atmos Environ (1994)

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Inhibition of ferroptosis rescues M2 macrophages and alleviates arthritis by suppressing the HMGB1/TLR4/STAT3 axis in M1 macrophages