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There are four factors that are able to upregulate VEGF expression: hypoxia, inflammatory cytokines, nerve signals and mechanical load (Pufe et al., 2005

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Adults dealing with high daily pollution exposure in metro cities Vegetarians and vegans with limited sulfur-amino-acid intake Anyone training intensely and wanting extra antioxidant support Adults past their early 30s, when natural production is thought to gradually decline Hold off if: you're pregnant or breastfeeding, undergoing chemotherapy, on thyroid or chronic-illness medication, or simply unsure these situations need a doctor's sign-off before starting any new antioxidant supplement

Fatigue, lightheadedness, and overall weakness are the most common symptoms of low B12