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The insulin-like growth factor 1 (IGF-1) is a hormone widely expressed throughout the body that plays a crucial role in promoting anabolic processes

PINK1 and Parkin have been identified as regulators of multiple structural domains of mitochondrial quality control, with additional roles in mitochondrial biogenesis and mitophagy (Lee H

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Endocrinology (2005) 146:225564

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Cell lines Human pancreatic cancer cell lines (PANC-1 and BxPC-3) were purchased from the Chinese Academy of Sciences Cell Bank of Type Culture Collection (Shanghai, China)