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Overall, these findings suggest that while several interventions produced improvements of clinical importance, effects were inconsistent across studies

doi: 10.1023/a:1006896832582

Therefore, design and development of efficient topical therapeutic agents would be promising in melasma management not only to induce optimum clinical response, but also avoid unwanted adverse drug reactions and relapse through the enhance in water solubility, increase the skin permeability, augment the photostability, and improve the dermal bioavailability of the loaded drugs

doi: 10.3390/biom15030327 87 WaltherTCFareseRVJr

Available from: 37.Office of Dietary SupplementsZinc [Internet]

Therefore, it can be hypothesized that inorganic selenium will produce a rapid, important and persistent response on Se-GSH-Px, whether or not the enzyme is needed