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In addition to thiol oxidation leading to disulfide bond formation by reactive oxygen species (ROS) (Suzuki et al, 2019), KEAP1 cysteine residues undergo S-alkylation by various endogenous and/or exogenous electrophiles (Wu and Papagiannakopoulos, 2020), such as succination by fumarate (Ooi et al, 2011

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He assisted in the design of the study, performed the statistical analysis, and assisted in the preparation of the manuscript

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252,253,254,255 Disruptions in energy metabolism can result in insufficient cellular energy, oxidative stress, and cellular injury, leading to neuronal malnutrition, structural changes, and functional loss

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It means that body temperature during fever in old rats was significantly lower than that recorded in young rats

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