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The pronounced IgG2a/c responses are consistent with IFN--driven class switching, supporting T-cell-dependent pathways that contribute to humoral immunity (4042)

Monitor thyroid function in patients with pre-existing thyroid conditions, as liothyronine may affect systemic thyroid hormone levels

doi:10.1016/j.exger.2014.06.013

Two independent mechanisms = a potentially synergistic combination

The exact cellular mechanisms underlying the synthetic lethality of RSL3 on BRAF/RAS mutant PTC cells remain to be determined

In addition, combination of ganitumab with metformin is being tested in an ongoing I-SPY2 trial, which aims to identify most effective agents to treat various types of breast cancer and learn about the predictors of treatment response [155]