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Conversely, CO-GHD patients tend to be less insulin-resistant than AO-GHD patients (84), and their IGF-I levels are generally lower than their AO-GHD counterparts due to relatively lower intra-portal insulin levels

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A cross-sectional analysis of biomarkers confirmed higher pro-atherogenic non-HDL-C, ApoB, and ApoB/HDL ratios during the low-estrogen follicular phase, with remnant cholesterol (a TG-rich lipoprotein marker) elevated luteally and uncorrelated with estrogen [126]

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[DOI] [PubMed] [Google Scholar] [134].Meng Q, Shi S, Liang C, Liang D, Hua J, Zhang B, Xu J, Yu X, Abrogation of glutathione peroxidase-1 drives EMT and chemoresistance in pancreatic cancer by activating ROS-mediated Akt/GSK3beta/Snail signaling