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In both in vivo patient-derived xenograft models and in vitro patient-derived organoid models, high-MCU PDAC show increased sensitivity to SLC7A11 inhibition compared to low-MCU tumors, 163 suggesting that MCU-mediated ferroptosis could serve as a therapeutic strategy to prevent PDAC tumor metastasis

Data availability The data that support the findings of this study are available on request from the corresponding author

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Liu J, Bi X, Chen T, Zhang Q, Wang SX, Chiu JJ

T.KonstorumA.DengZ.CoxA

Thus, the demethylation of the IL27RA promoter by procainamide restored the activation of this gene, which is known to have an anti-inflammatory effect in several models of inflammation