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Gatekeeper mutation Mutation that alters an amino acid residue at a specific location in the ATP-binding site of a kinase, known as the gatekeeper residue
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Step 6 Scale-Up Validation & Stability Stress Testing The final formulation undergoes accelerated stability testing (temperature, light) and compatibility checks with common cosmetic excipients
doi: 10.1136/bmj.315.7109.629 30
However, not every protein shows the same concentration-dependent viscosity increase
K., Kucukunal, N
