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The dose of vitamin B12 shots depends on how bad the deficiency is and the type of B12 used

Overall Evidence for the Use of B12 for Painful Peripheral Polyneuropathy Taking into account the above evidence, there is level III evidence overall to support the use of B12 either as monotherapy or as a combination therapy for treating neuropathic pain caused by peripheral polyneuropathy

Anaphylactic shock and death have been reported after parenteral Vitamin B12 administration

The rationale is an extrapolation from two separate preclinical stories, stitched together by marketing and community folklore

While oral administration is convenient and suitable for at-home antibiotic therapy, it is associated with a decline in the concentration of the active compound upon reaching the infection site (Homayun et al., 2019

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