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During periods of stress, fish experience increased oxidative stress due to elevated ROS production

543 Among these proteins is 4E-binding protein 1 (4E-BP1), a negative regulator of translation that buffers the proteome against MYC-induced misfolding

Third, ROS promotes microvascular insufficiency by oxidizing BH4, leading to eNOS uncoupling and reduced endoneurial blood flow, with clinical studies showing a strong inverse correlation between skin biopsy-measured intraepidermal nerve fiber density and serum 8-OHdG levels (Carnicer et al., 2021)

PubMed PMID: 8250714 Mari R, Le Biez E, Busson P, et al

Endocrinology 2001, 142 (8), 33323339

[DOI] [PMC free article] [PubMed] [Google Scholar] Hozo 2005 Hozo SP, Djulbegovic B, Hozo I