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Peer-reviewed and received in revised form 11 January 2022

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60 Dosages ranged from 2 g per day p.o

Arthritis is the most common cause of Spinal Stenosis, as it causes facet joints to expand, leaving little room for nerve roots

NO DAC human pharmacokinetics remain poorly characterized Ipamorelin human data limited to early-phase pharmacokinetic and pharmacodynamic studies with small sample sizes Safe and effective dosing parameters for humans are unknown for the blend Long-term safety of sustained GH and IGF-1 elevation through secretagogue use is unstudied in human subjects Mechanistic Understanding The 3- to 5-fold synergistic GH release figure derives primarily from animal models and in vitro work