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they are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or in those with multiple endocrine neoplasia syndrome type 2

However, a personal or family history of medullary thyroid cancer is an absolute contraindication

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Data were summarized with Mantel-Haenszel odds ratio (OR) with direct meta-analysis to compare the GLP-1 agonist group with the control group

moderate renal impairment (eGFR 30-45 ml/min) has been observed to increase plasma levels of sitagliptin 2-fold, and severe renal impairment can increase plasma levels 4-fold