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Regarding the few pathways where the result seems incongruous, when analyzing their topology, it is clear that their activation by B12 is potentially beneficial to the patient

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Consistent with our RNA-seq data, we also observed increased protein abundances for those in the pentose phosphate and Entner-Doudoroff pathways, including phosphogluconate aldolase (Eda) and 6-phosphogluconolactonase (Pgl), with fold changes of approximately 6-fold and 8.5-fold, respectively (Additional Table S3)

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Mol Cancer Ther (2016) 15:163747

Are there any side effects from B12