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Regarding liver function, CoQ10 is primarily metabolised by the liver, and this organ naturally contains high concentrations of the compound

Senescent stimuli endow cells with resistance to apoptosis, which involves high activity of anti-apoptotic molecules, such as BCL2 and BCL-XL, and reduced pro-apoptotic BAX protein

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or i.g., without adverse effects was shown in mice, and a lethal dose (LD1) was not achieved, which also shows metabolites without harmful effect [3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21,22,23,24,27,28,29,30,31,32,34,37,39,40]

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doi: 10.1016/S1386-6346(03)00115-3