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Melatonin levels in early life are crucial for vascular health, promoting vasodilation, reducing oxidative stress, and supporting endothelial function

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BBR has surfaced as a potential antidiabetic compound through several mechanisms: (a) activation of AMPK via Thr172 phosphorylation, which lowers blood glucose levels, inhibits hepatic gluconeogenesis, and promotes glucose uptake in muscles [81,82]

By examining both epithelial and stromal contributions to ferroptosis-driven pathology, we aim to provide a framework for identifying novel targets for disease interception and treatment

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