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This rheological shift directly propagates into high-speed rotary presses (exceeding 300,000 tablets per hour) as erratic die fill, weight variation exceeding 5% RSD, and punch-face sticking that mars tablet surfaces

doi:10.1016/j.explore.2021.09.006 Originally published in 2021, this article has been revised and updated for accuracy and thoroughness.

The normal pathways for the synthesis of 2-HG utilize 2-oxoglutarate (-ketoglutarate) or -hydroxybutyrate (GHB) as the substrate