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Research has demonstrated that long-term administration of L-theanine (400 mg daily) had antistress effects by reducing the salivary -amylase and subjective stress (Unno et al., 2013)

Arch Int Med 1981

26 and the references therein), they have limitations associated with well-known multiple adverse reactions, genotoxicity, and special requirements for storage, handling, and administration, posing challenges with respect to the standard operating procedure (SOP) for MDA campaigns requiring single or double dose activity, oral administration, minimal toxicity, and stability in tropical settings 27

10.12659/MSM.922248 52 ShenP.JiS.LiX.YangQ.XuB.WongC

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Once activated, microglia release pro-inflammatory cytokines such as TNF- and IL-6, which intensify brain inflammation and cause further neuronal damage