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Experimental data indicate that GHK-Cu can influence collagen and glycosaminoglycan synthesis, modulate proteoglycan and chondroitin sulfate turnover, and recruit fibroblasts, immune cells, and endothelial cells to sites of tissue injury

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When L-arginine is employed as a medication for cardiovascular diseases, it presents the following drawbacks: when the arginine level is excessively high, it will enhance the expression of arginase, thereby resulting in more arginine decomposition, which can increase gastrointestinal irritation, L-citrulline avoids these issues, making it a preferable supplement [66]

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