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Machado et al

1000 :

In contrast, deletion of Bmal1 led to only a partial reduction in CI respiration and a milder metabolic phenotype

indicado como hepatoprotetor e como coadjuvante no tratamento de cirrose heptica em alcolatras, tem efeito anti-inflamatrio, atua no tratamento e preveno de doenas neurodegenerativas como Alzheimer e outras demncias

Deficiency of pyruvate dehydrogenase complex (PDHc), citrate synthase (CS), aconitase, 2- oxoglutarate dehydrogenase complex (OGDHc), succinate-CoA ligase (ligase), and the mitochondrial succinate transport due to inhibition by accumulating propionyl-CoA (P-CoA) and 2-methylcitrate (2-MCA), result in a synergistic impairment of energy metabolism, with a particular focus on the TCA cycle

M., Kroemer, G