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[234] observed that there was a strong relation between TNF- and Kyn, Kyn/tryptophan, 3-HK and QA in the manic subgroup whereas in the depressed subgroup the KYNA/3-HK decreased and there was a strong association between interferon-y and Kyn pathway activation

Many studies have demonstrated the importance of the Nrf2/ARE pathway in the pathogenesis and control of neurological disorders, including PD, AD, ischemia, and other neurodegenerative diseases

Glial cells (oligodendrocytes, astrocytes, microglia, and ependymal cells) can be activated by inappropriate dietary patterns, another possible cause of neuroinflammation

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Consequently , researchers use these models to study how cells manage collagen-related, elastin-related, and matrix-associated signaling processes

In addition, the validation results about the reliability of ABHA data were shown in Supplemental Results and Fig