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However, about 15 percent of the population has a vitamin B12 deficiency

Many patients seek treatment after noticing signs of aging, such as fine lines, wrinkles, uneven skin tone, loss of skin firmness, or diminished skin elasticity

Levels below 148 pmol/L are generally considered deficient, but neurological symptoms can occur with levels in the 'low-normal' range (148258 pmol/L)

The 20-30 hour half-life means the peptide still distributes systemically regardless of site, so any local-only effect is partial at best

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