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As he recalled '[I] did not find myself at all sympathetic to his approach, mainly because I could not see that this approach could cover the self-not-self differentiation crucial to all immunological theory' (Anderson, Mackay)

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doi: 10.1128/MCB.02132-06

The latter can occur naturally, such as the opioid peptide dermorphin isolated from frog skin, peptidoglycans of some microorganisms, or venom peptidesconotoxins containing D -tryptophan ( D -Trp), D -leucine ( D -Leu), etc

It follows logically that addressing multiple mechanisms simultaneously through carefully selected peptide combinations could produce outcomes exceeding what any single peptide achieves alone