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Future research should employ subtype-specific models and single-cell multi-omics to map molecular signatures, clarify how driver mutations shape pathway heterogeneity and validate these insights for targeted therapy development

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Hypothalamic Energy Homeostasis (ARCPVN Axis) Amylin receptor signaling in the arcuate nucleus (ARC) and paraventricular nucleus (PVN) of the hypothalamus modulates neuropeptide Y (NPY), AgRP, POMC, and CART expression, intersecting with leptin and GLP-1 receptor signaling networks