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How AOD-9604 Works (in Brief) AOD-9604 was engineered from the C-terminal segment of human growth hormone (amino acids 177191) the portion thought to influence fat metabolism. In preclinical models, this fragment supported fat oxidation and lipid mobilization without the broader hormonal effects of full-length hGH. Because it does not activate the traditional hGH receptor, its fat-metabolism effects are considered indirect and receptor-independent. Discovery & Research Milestones Originally developed in the 1990s as a potential anti-obesity drug

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First, current inhibitors such as GsMTx4 are nonspecific inhibitors that may adversely affect Piezo1 expression in normal tissues, increasing the risk of treatment side effects

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Now, theres growing focus on how the body regulates energy, metabolism and overall balance