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The main common triggers are stress, dehydration, lack of sleep, aging, weight loss/gain

Bromelain acted by removing the extracellular domains of the CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and thus enhancing T cell activation through CD2

PCOS, polycystic ovary syndrome

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doi: 10.1016/j.nutres.2008.03.003 [DOI] [PubMed] [Google Scholar] [423].Hadi A, Pourmasoumi M, Mohammadi H, et al

It also upregulates the expression of the gastrointestinal barrier proteins ZO-1 and occludin in MPTP-treated mice, improves intestinal barrier function and gastrointestinal dysfunction, and consequently exerts a neuroprotective effect indirectly via the gut-brain axis ( Another study demonstrated that administration of neohesperidin, the primary active component of citrus fruits (25 and 50 mg/kg, administered for 24 days), significantly alleviated MPTP-induced damage to dopaminergic neurons in the substantia nigra-striatal pathway of PD mice, increased levels of striatal dopamine (DA) and its metabolite DOPAC, and improved motor dysfunction