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Integrating UGT inhibition data into the rule-of-two model significantly enhances the prediction accuracy for drug-induced liver injury (DILI) (119)

Official product specifications and labeling information can be reviewed through the Pfizer labeling document linked above

[30] Release of GSTs as an indication of organ damage [edit] The high intracellular concentrations of GSTs coupled with their cell-specific cellular distribution allows them to function as biomarkers for localising and monitoring injury to defined cell types

Anti-inflammatory activity of methanol extract of Phellinus linteus through inhibition of nitric oxide production and inducible nitric oxide synthase expression

Despite this, a number of genes within each family responded quite similarly to the different oxidative stresses

6.3 Risk monitoring and safety considerations Safety remains a critical aspect of implementation