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On the other hand, elevated intracellular ROS levels can activate programmed cell death and release a large amount of cellular content, activating the bodys immune system to eliminate the tumor [9]

[DOI] [PubMed] [Google Scholar] 295.Preston A.M., Rodriguez C., Rivera C.E., Sahai H

Unfortunately, no measurements of free iron in these FTH-silenced CSCs were performed, but it is plausible that increased levels of free iron would be expected

FRDA fibroblasts treated with exogenous stress to induce the Nrf2 response indeed could not induce proper antioxidant compensation including upregulation of catalase, NQO1, and GST-P1 after t BHQ treatment or catalase, GST-P1, and SOD2 after oligomycin treatment

Animal models UM-SCC6 cells (2 10 6 cells per mouse) were injected into the subcutaneous space of nude mice aged 6 weeks old (about 18 g, female)

[DOI] [PMC free article] [PubMed] [Google Scholar] 230.Lundgren S.N., Madan J.C., Emond J.A., Morrison H.G., Christensen B.C., Karagas M.R., Hoen A.G