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Meanwhile, according to the lung histology score of inflammation, GSTP remarkably reduced the inflammatory infiltrate increased in CLP mice, which might lead to the decrease of the higher level of HMGB1 found in the serum and mortality of mice (Figures 1AC)

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SOD enzyme can react with O 2 - radicals and inhibit the formation of formazan

The large number of IGFBPs, IGFBP-rPs as well as other carrier proteins affect bioavailability of IGF-1 in circulation and reduces significantly the levels of immunoreactive IGF-1 in serum samples, requiring multiple pre-treatment steps that reduce reproducibility and complicates interpretation of IGF-1 assay results

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Then, the ubiquitinated target protein is sent to the proteasome, a protein complex that will degrade the target protein into small peptides (Micel et al, 2013)