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NCT02032823) will The cytoplasmic mic kinases known as non-receptor tyrosine kinases (NRTKs) include MEK (Mitogen-activated extracellular signal-regulated kinase), Src, and the PI3-AKT-mTOR signalling cascade (68, 69)

doi: 10.1530/JOE-17-0023 66 BorowskaMCzarnywojtekASawicka-GutajNWoliskiKPaziskaMTMikoajczakPet al

Sorafenib upregulates ABCC5 via the PI3K/Akt/Nrf2 pathway, which inhibits lipid peroxidation-mediated ferroptosis and promotes cancer growth, resulting in acquired sorafenib resistance in human HCC cells, according to Huang et al (91)

For tesamorelin, known adverse effects (based on US and Canadian prescribing information, as no UK Summary of Product Characteristics exists) include: Fluid retention (oedema, joint pain, carpal tunnel syndrome) Elevated blood glucose and reduced insulin sensitivity due to GH elevation Injection site reactions Raised IGF-1 levels active malignancy is a key contraindication