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[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Balakumar P., Rohilla A., Krishan P., Solairaj P., Thangathirupathi A

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PERK induces phosphorylation for the eIF2 and promotes ATF4, thereby protecting the cell from oxidation (Sureda et al., 2020), while NTZ upregulates the ATF4 (Ashiru et al., 2014), demonstrating antioxidant activity

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Although the precise mechanism remains unclear, this approach has gained wide clinical use

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The study of ferroptosis is still undergoing and there are many unsolved mysteries such as the drivers of LPO, the subcellular location of lethal lipid peroxides and the exact mechanism of LPO leading to cell death [137]

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The limited available studies on this topic from the PubMed database include a 2011 review paper that relied on older datasets ( in-utero ATZ exposure, instead of looking at the correlation between in-utero ATZ exposure and the age of menarche ( Figure 1D ) ( in-utero ATZ exposure and breast cancer should be examined

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