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TNF- acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle

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By aiding in fat metabolism, it provides the muscles with an additional energy source, potentially reducing fatigue

Michailidou Z (2019) Fundamental roles for hypoxia signalling in adipose tissue metabolism and inflammation in obesity

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Neoplasia 12 , 599607 (2010)