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Another systemic strategy is the administration of antibodies (e.g., infliximab anti-TNF- in the treatment of recalcitrant ulcerating necrobiosis lipoidica) or peptides (e.g., neuropeptide -melanocyte-stimulating hormone -MSH)

Prog Brain Res 250:179216 Herculano-Houzel S, Manger PR, Kaas JH (2014) Brain scaling in mammalian evolution as a consequence of concerted and mosaic changes in numbers of neurons and average neuronal cell size

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doi: 10.1038/s41598-020-71908-9