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Recent studies highlight the potential of targeting the ZZ domain of p62 using XRK3F2, a small-molecule inhibitor, to enhance the therapeutic efficacy of bortezomib in MM

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The dose converted to mice was 146.37 mg/kg, according to the classical formulate of pharmacology and toxicology [38]

[43] This epigenetic drift theory suggests that cumulative changes in DNA methylation, histone modifications, and chromatin remodeling over time contribute to neurodegeneration, providing a potential link between aging and late-onset Alzheimer's disease

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subtilis CP34, achieved 91% degradation of 100 ppm chlorpyrifos after 6 days of incubation at 30 C and pH 7, demonstrating its effectiveness in remediating chlorpyrifos-contaminated environments (Varghese et al., 2021)