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Uncontrolled neutrophil activity in chronic wounds results in excessive ROS release, which activates NFB which propagates inflammation, upregulation of IL1, 8, and TNF resulting in a positive feedback loop

This is one of its most clinically significant features, and one reason researchers continue to study it for complex neurological conditions where single-target interventions have shown limited efficacy

10.1002/glia.22689 45 CliffeA

linear proliferative phase), which may take between 48 to 72 hours

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