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Description
The overall strategy is illustrated in Scheme 1

Alroy, D

AGC1 and AGC2 are members of a family of Ca 2+ -dependent mitochondrial carriers (CaMC)

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A wide variety of functional assays, both in vivo and ex vivo, include various measures of total reactive oxygen species (ROS measured in blood components

Interestingly, the vasoprotective properties of NOX4 are attributed to the NOX4-derived H 2 O 2 that can cross the membrane and act as a signaling molecule or even endothelium-derived relaxation factor (EDRF), activating downstream effectors and inducing cardiac and vascular protection [56,58]
