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Moreover, NO seems to be the only mediator of cell proliferation arrest through the ERK1/2-p53 signaling pathway ( FIGURE 1 Next to this evidence, in our laboratory it has been demonstrated that GSH depletion modulates the peroxisome proliferator-activated receptor gamma, co-activator 1 alpha (PGC-1) expression and its downstream metabolic pathway in neuronal and skeletal muscle cells ( Figure 1 )

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HGH binds the GHR on hepatocytes, activating the JAK2/STAT5 signaling cascade and stimulating transcription of the IGF-1 gene, producing 70% of circulating IGF-1

[DOI] [PubMed] [Google Scholar] 16.Ha K.N., Chen Y