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Genome-wide studies have demonstrated that nuclear receptors regulate gene expression by direct DNA binding, but that nuclear receptors can also assist in opening chromatin at noncanonical sites and influence gene expression in ways distinct from direct DNA binding (71)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 131.Kita K., Kato S., Amanyaman M., Okumura J., Yokota H

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Fukawa T, Yan-Jiang BC, Min-Wen JC, Jun-Hao ET, Huang D, Qian C-N, et al

10.1093/humupd/3.5.467 47